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A controversial diet touted as top for weight loss may help people with the most common inherited kidney disease that accounts for 10% of kidney failure cases
Possible nutritional treatment could be the ketogenic diet for people with Autosomal Dominant Polycystic Kidney Disease (ADPKD)the most common hereditary nephropathy responsible for 10% of renal failure cases.
The above was concluded by researchers led by Dr. Roman-Ulrich Müller from the University Hospital of Cologne and the Aging Research Excellence Cluster CECAD research center, whose findings are published in the scientific journal Cell Reports Medicine. In November 2022, Dr. Müller presented the preliminary findings at the American Society of Nephrology’s Kidney Week.
Results in three months
The 66 patients who participated in the study were divided into three groups, one of which followed ketogenic diet -mostly fat, less protein and minimal carbohydrates- for three months, one group water fasting -only water allowed- for three days each month and one that remained within official dietary recommendations such as starchy foods, lots of fruit and vegetables and good sources of protein.
Against researchers’ reservations95% of ketogenic diet participants and 85% of the water fasts stated that adherence to the new diet plan was achievable. For the first group, the researchers measured ketone bodies (alternative energy sources instead of glucose) in the blood samples to see if they had actually followed the guidelines.
In just three months, according to the results, statistically significant were observed positive changes in nodal parameters such as kidney function, without unexpected side effects.